5-Bromoindole → 5-Bromoindoline

HRID 356032Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.C([BH3-])#N.[Na+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][CH2:5]2

Participants

Reactant 2

HCID 249055-Bromoindole

HCID 5003444Sodium cyanoborohydride

Product 1

HCID 34115665-BromoindolineYield 71%

Procedure

5-Bromoindole (0.7 g, 3.6 mmol) was treated with sodium cyanoborohydride as in the method of Description 10 to yield the title compound (0.5 g, 71%).

Sources & evidence

ORD record: ord-949ff44e6d7c45ba94b489f276085474
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05834494

Reaction notes

Loading…