Sodium cyanoborohydride → HCID 10608491, compound

HRID 356035Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][C:3]=1[C:11]([CH3:14])([CH3:13])[CH3:12].C([BH3-])#N.[Na+]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[C:11]([CH3:14])([CH3:13])[CH3:12]

Participants

Reactant 2

HCID 5003444Sodium cyanoborohydride

HCID 10822233HCID 10822233, compound

Product 1

HCID 10608491HCID 10608491, compoundYield 72%

Procedure

6-Chloro-5-tert-butylindole (D55) (0.29 g, 1.40 mmol) was treated with sodium cyanoborohydride as in the method of Description 10 to give the title compound (0.21 g, 72%) as a yellow oil.

Sources & evidence

ORD record: ord-7bc62dbc9abb4f7eb0f2a2350d74b85b
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05834494

Reaction notes

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