3-Isocyanatopyridine → HCID 10710785, compound

HRID 356058Notes

Reaction equation

HRID 356058 reaction equation
[Cl:1][C:2]1[C:10]([S:11][CH3:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][NH:6]2.[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N:19]=[C:20]=[O:21])[CH:14]=1>>[Cl:1][C:2]1[C:10]([S:11][CH3:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][N:6]2[C:20](=[O:21])[NH:19][C:15]1[CH:14]=[N:13][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 18940897HCID 18940897, compound

Product 1

HCID 10710785HCID 10710785, compoundYield 84%

Procedure

4-Chloro-5-methylthioindoline (D49) (0.9 g, 4.51 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The crude product was filtered-off and recrystallised from ethanol to give the title compound (1.22 g, 84%) as a white crystalline solid m.p. 237°-241° C.

Workup

  1. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-ba4d324284f4471aa6fb3c776d733e43
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

Loading…