3-Isocyanatopyridine → HCID 10518435, compound

HRID 356060Notes

Reaction equation

HRID 356060 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[CH2:11][CH3:12].[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N:19]=[C:20]=[O:21])[CH:14]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:20](=[O:21])[NH:19][C:15]2[CH:14]=[N:13][CH:18]=[CH:17][CH:16]=2)=[CH:4][C:3]=1[CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 18940898HCID 18940898, compound

Product 1

HCID 10518435HCID 10518435, compoundYield 59%

Procedure

6-Chloro-5-ethylindoline (D52) (0.42 g, 2.33 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The crude product was recrystallised from ethanol/diethyl ether to give the title compound (0.42 g, 59%) as a white crystalline solid m.p.=227° C.

Workup

  1. customThe crude product was recrystallised from ethanol/diethyl ether

Sources & evidence

ORD record
ord-f2175825a4f24d35bca6823bd4dca5b3
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

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