3-Isocyanatopyridine → HCID 10687827, compound

HRID 356063Notes

Reaction equation

HRID 356063 reaction equation
[Cl:1][C:2]1[C:10]([C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][NH:6]2.[N:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N:21]=[C:22]=[O:23])[CH:16]=1>>[Cl:1][C:2]1[C:10]([C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][N:6]2[C:22](=[O:23])[NH:21][C:17]1[CH:16]=[N:15][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 10632224HCID 10632224, compound

Product 1

HCID 10687827HCID 10687827, compoundYield 58%

Procedure

4-Chloro-5-tert-butylindoline (D57) (0.45 g, 3.04 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The product was recrystallised from ethanol/diethyl ether to give the title compound (0.46 g, 58%) as a white crystalline solid m.p.=174°-176° C.

Workup

  1. customThe product was recrystallised from ethanol/diethyl ether

Sources & evidence

ORD record
ord-cd6e00dc51fb4a0c96c36f4b9e1c1cf1
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

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