3-Isocyanatopyridine → HCID 18940921, compound

HRID 356067Notes

Reaction equation

HRID 356067 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[S:11][CH:12]([CH3:14])[CH3:13].[N:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N:21]=[C:22]=[O:23])[CH:16]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:22](=[O:23])[NH:21][C:17]2[CH:16]=[N:15][CH:20]=[CH:19][CH:18]=2)=[CH:4][C:3]=1[S:11][CH:12]([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 18940936HCID 18940936, compound

Product 1

HCID 18940921HCID 18940921, compoundYield 61%

Procedure

6-Chloro-5-isopropylthioindoline (D66) (0.35 g, 1.52 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The crude product was recrystallised from ethanol/diethyl ether to give the title compound (0.33 g, 61%) as a white crystalline solid m.p. 199°-201° C.

Workup

  1. customThe crude product was recrystallised from ethanol/diethyl ether

Sources & evidence

ORD record
ord-e16d98046cf7445d801316ec65781179
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

Loading…