3-Isocyanatopyridine → HCID 9976912, compound

HRID 356069Notes

Reaction equation

HRID 356069 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[S:11][CH2:12][CH3:13].[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([N:20]=[C:21]=[O:22])[CH:15]=1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:21](=[O:22])[NH:20][C:16]2[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=2)=[CH:4][C:3]=1[S:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 18940893HCID 18940893, compound

Product 1

HCID 9976912HCID 9976912, compoundYield 70%

Procedure

6-Bromo-5-ethylthioindoline (D84) (0.28 g, 1.09 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The product was recrystallised from ethanol/diethyl ether to yield the title compound (0.29 g, 70%) as an off-white crystalline solid m.p. 226°-227° C.

Workup

  1. customThe product was recrystallised from ethanol/diethyl ether

Sources & evidence

ORD record
ord-fe3c2d5b17f14000bbbc3a6dc1742be4
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

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