Ammonia → HCID 18941023, compound

HRID 356108Notes

Reaction equation

HRID 356108 reaction equation
[C:1]([O:5][C:6]([N:8]1[C:14](=[S:15])[CH:13]2[CH:9]1[CH2:10][CH2:11][CH2:12]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:16]>CO>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:10][CH2:11][CH2:12][CH:13]1[C:14](=[S:15])[NH2:16])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18941027HCID 18941027, compound

Product 1

HCID 18941023HCID 18941023, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 42 ml of 29% aqueous ammonia and 60 ml of methanol, 1.48 g of 6-tert-butoxycarbonyl-6-azabicyclo[3.2.0]heptane-7-thione was dissolved, followed by stirring at room temperature for 30 minutes. The solvent was azeotropically evaporated using benzene-ethanol, whereby 1.39 g of 2-(tert-butoxycarbonylamino)cyclopentanecarbothioamide was obtained as the crystal form.

Workup

  1. customThe solvent was azeotropically evaporated

Sources & evidence

ORD record
ord-d84fb4f9c0dc4d93b1a527826df6d64c
Source dataset
uspto-grants-1998_11
Patent number
US05834499

Reaction notes

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