Ethanol hydrochloride → HCID 70111952, compound

HRID 356153Notes

Reaction equation

HRID 356153 reaction equation
[ClH:1].C(O)C.[CH2:5]([N:12]1[CH2:18][C@@H:17]2[CH2:19][CH2:20][CH2:21][C@H:16]2[NH:15][C:14]2[CH:22]=[CH:23][CH:24]=[CH:25][C:13]1=2)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(O)C>[ClH:1].[CH2:5]([N:12]1[CH2:18][C@@H:17]2[CH2:19][CH2:20][CH2:21][C@H:16]2[NH:15][C:14]2[CH:22]=[CH:23][CH:24]=[CH:25][C:13]1=2)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 70111953HCID 70111953, compound

Product 1

HCID 70111952HCID 70111952, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol was dissolved (3aR*,10aS*)-9-benzyl-1,2,3,3a,4,9,10,10a-octahydrobenzo[b]cyclopenta-[e][1,4]diazepine produced in Working Example 42. To the solution was added a 2.43N HCl-ethanol solution. This solution was concentrated under reduced pressure, and the concentrate was crystallized from ethanol to give the titled compound, m.p. 177°-179° C.

Workup

  1. customproduced in Working Example 42
  2. concentrationThis solution was concentrated under reduced pressure
  3. customthe concentrate was crystallized from ethanol

Sources & evidence

ORD record
ord-abc4baa8168c48a48972e7c78ba9af1c
Source dataset
uspto-grants-1998_11
Patent number
US05834463

Reaction notes

Loading…