Ethanol hydrochloride → HCID 70112645, compound

HRID 356154Notes

Reaction equation

HRID 356154 reaction equation
[ClH:1].C(O)C.[CH2:5]([N:12]1[CH2:18][C@@H:17]2[CH2:19][CH2:20][CH2:21][C@H:16]2[N:15]([CH3:22])[C:14]2[CH:23]=[CH:24][CH:25]=[CH:26][C:13]1=2)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(O)C>[ClH:1].[CH2:5]([N:12]1[CH2:18][C@@H:17]2[CH2:19][CH2:20][CH2:21][C@H:16]2[N:15]([CH3:22])[C:14]2[CH:23]=[CH:24][CH:25]=[CH:26][C:13]1=2)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 70109971HCID 70109971, compound

Product 1

HCID 70112645HCID 70112645, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol was dissolved (3aR*,10aS*)-9-Benzyl-4-methyl-1,2,3,3a,4,9,10,10a-octahydrobenzo[b]-cyclopenta[e][1,4]diazepine produced in Working Example 43. To the solution was added a 2.43N HCl-ethanol solution, which was concentrated under reduced pressure. The concentrate was dissolved in ethanol-ether, which was concentrated to dryness. Amorphous.

Workup

  1. customproduced in Working Example 43
  2. concentrationwas concentrated under reduced pressure
  3. dissolutionThe concentrate was dissolved in ethanol-ether
  4. concentrationwhich was concentrated to dryness

Sources & evidence

ORD record
ord-48580f968bb14b80b1aeac083c1ec9a5
Source dataset
uspto-grants-1998_11
Patent number
US05834463

Reaction notes

Loading…