2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo- → HCID 18940585, compound

HRID 356157Notes

Reaction equation

HRID 356157 reaction equation
[CH2:1]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][CH:11]([CH3:19])[CH2:10][C:9]1=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21]1(=[O:35])[N:25]([CH2:26][C:27](Cl)=[O:28])[C:24](=[O:30])[C:23]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:22]12>C(OCC)C>[CH2:1]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([C:27](=[O:28])[CH2:26][N:25]2[C:24](=[O:30])[C:23]3=[CH:31][CH:32]=[CH:33][CH:34]=[C:22]3[C:21]2=[O:35])[CH:11]([CH3:19])[CH2:10][C:9]1=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 812422H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-HCID 18940573HCID 18940573, compound

Product 1

HCID 18940585HCID 18940585, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The titled compound was synthesized from 1-benzyl-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one and phthalimidoacetyl chloride in substantially the same manner as in Working Example 46. Yield 61%. m.p. 248°-250° C. (diethyl ether).

Sources & evidence

ORD record
ord-afd7f1de7eb046a68316ae6909a71a32
Source dataset
uspto-grants-1998_11
Patent number
US05834463

Reaction notes

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