HCID 18940559, compound → HCID 18940542, compound

HRID 356186Notes

Reaction equation

HRID 356186 reaction equation
[CH2:1]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][CH:11](/[CH:19]=[CH:20]/[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:10][C:9]1=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pt]=O>[CH2:1]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][CH:11]([CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:10][C:9]1=[O:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 18940559HCID 18940559, compound

Product 1

HCID 18940542HCID 18940542, compoundYield 203.3%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

A suspension of 1-benzyl-4-((E)-styryl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one (0.51 g, 0.69 mmol) and platinum oxide (50 mg) in methanol (20 ml) was stirred for 3 hours at room temperature under hydrogen atmosphere. The reaction mixture was subjected to filtration. The solvent of the filtration was distilled off, and the residue was crystallized from diethyl ether to give 500 mg (yield 98%) of the titled compound, m.p. 135°-137° C.

Workup

  1. filtrationThe reaction mixture was subjected to filtration
  2. filtrationThe solvent of the filtration
  3. distillationwas distilled off
  4. customthe residue was crystallized from diethyl ether

Sources & evidence

ORD record
ord-092b656d0be542dc8cb33bdee209f7b7
Source dataset
uspto-grants-1998_11
Patent number
US05834463

Reaction notes

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