Diethyl Ether → HCID 70113406, compound

HRID 356190Notes

Reaction equation

[CH2:1]([N:8]1[C:14](=[O:15])[C@H:13]2[CH2:16][CH2:17][CH2:18][C@H:12]2[N:11]([C:19](=[O:32])[CH2:20][NH:21][C:22](=[O:31])[CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:10]2[CH:33]=[CH:34][CH:35]=[CH:36][C:9]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:37]([O:39]CC)[CH3:38]>>[C:37]([N:21]([CH2:20][C:19]([N:11]1[C@@H:12]2[CH2:18][CH2:17][CH2:16][C@@H:13]2[C:14](=[O:15])[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9]2[CH:36]=[CH:35][CH:34]=[CH:33][C:10]1=2)=[O:32])[C:22](=[O:31])[CH2:23][CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)(=[O:39])[CH3:38]

Participants

Reactant 2

HCID 3283Diethyl Ether

HCID 70112413HCID 70112413, compound

Product 1

HCID 70113406HCID 70113406, compoundYield 76%

Procedure

Using (3aR*,10aS*)-9-benzyl-4-((3-phenylpropionamido)acetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one, the titled compound was synthesized in substantially the same manner as in Working Example 109 in a yield of 76%, m.p. 138°-140° C. (diethyl ether).

Sources & evidence

ORD record: ord-fc8c315a3bc34053815668ba6c3199c3
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05834463

Reaction notes

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