HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetyl bromide → (3aR*,10aS*)-4-(Bromoacetyl)-9-(4-nitrobenzyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]-diazepin-10(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Reactant | (3aR*,10aS*)-9-(4-Nitrobenzyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one | HCID 54563031 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | (3aR*,10aS*)-4-(Bromoacetyl)-9-(4-nitrobenzyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]-diazepin-10(1H)-one | HCID 70110396 | 37% |
Reaction Steps
Using (3aR*,10aS*)-9-(4-nitrobenzyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]-diazepin-10(1H)-one and bromoacetyl bromide, the titled compound was synthesized in substantially the same manner as in Working Example 185 in a yield of 37%, m.p. 160.5°-161.5° C. (ethyl acetate-hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05834463 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-0d21f1acec9842dea40c3d33d999461b |
| Source note | uspto-grants-1998_11 |