Trifluoroacetic acid → 5-[4-{2-(7-Azaindol-1-yl)ethoxy]benzyl}thiazolidine-2,4-dione

HRID 356244Notes

Reaction equation

HRID 356244 reaction equation
[N:1]1([CH2:10][CH2:11][O:12][C:13]2[CH:45]=[CH:44][C:16]([CH2:17][CH:18]3[S:22][C:21](=[O:23])[N:20](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[C:19]3=[O:43])=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1.FC(F)(F)C(O)=O>C(Cl)Cl>[N:1]1([CH2:10][CH2:11][O:12][C:13]2[CH:14]=[CH:15][C:16]([CH2:17][CH:18]3[S:22][C:21](=[O:23])[NH:20][C:19]3=[O:43])=[CH:44][CH:45]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23298299HCID 23298299, compound

Product 1

HCID 107376995-[4-{2-(7-Azaindol-1-yl)ethoxy]benzyl}thiazolidine-2,4-dioneYield 55.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A procedure similar to that described in Example 2 was repeated, except that 2.50 g of 5-{4-[2-(7-aza-indol-1-yl)ethoxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione (prepared as described in Preparation 19), 50 ml of methylene chloride and 3.1 ml of trifluoroacetic acid were used, to give 0.84 g of the title compound, melting at 200.0°-202.4° C.

Sources & evidence

ORD record
ord-4738f779728c440fa9f578913c784e91
Source dataset
uspto-grants-1998_11
Patent number
US05834501

Reaction notes

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