反应详情

A procedure similar to that described in Preparation 43 was repeated, except that 4.15 g 3-amino-6-ethoxy-2-methylaminopyridine (prepared as described in Preparation 97), and 5.66 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 3.20 g of the title compound, melting at 161° C.

1. customA procedure similar to that described in Preparation 43
2. customthat the product was purified by column chromatography through silica gel
3. additionby volume mixture of ethyl acetate and methanol as the eluent