Diethylamine → N,N-Diethyl-2,5-bis(trifluoromethyl)benzamide

HRID 356359Notes

Reaction equation

HRID 356359 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:4]=1[C:5](Cl)=[O:6].[CH2:18]([NH:20][CH2:21][CH3:22])[CH3:19]>>[CH2:18]([N:20]([CH2:21][CH3:22])[C:5](=[O:6])[C:4]1[CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=[CH:11][C:3]=1[C:2]([F:17])([F:16])[F:1])[CH3:19]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 27378122,5-Bis(trifluoromethyl)benzoyl chloride

Product 1

HCID 15832108N,N-Diethyl-2,5-bis(trifluoromethyl)benzamide

Procedure

N,N-Diethyl-2,5-bis(trifluoromethyl)benzamide was prepared from 2,5-bis(trifluoromethyl)benzoyl chloride and diethylamine according to General Method E1. The desired intermediate was isolated in quantitative yield (11.3 g) without additional purification.

Sources & evidence

ORD record
ord-c9b3ea78aedb475a846a90dde56a0e4a
Source dataset
uspto-grants-1998_11
Patent number
US05834447

Reaction notes

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