Propargylamine → HCID 18630265, compound

HRID 356396Notes

Reaction equation

HRID 356396 reaction equation
[CH2:1]([NH:3][C:4](=[O:16])[C:5]1[C:10]([Si:11]([CH3:14])([CH3:13])[CH3:12])=[CH:9][CH:8]=[CH:7][C:6]=1[I:15])[CH3:2].[CH2:17](N)C#C>>[I:15][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([Si:11]([CH3:14])([CH3:13])[CH3:12])[C:5]=1[C:4]([NH:3][CH2:1][C:2]#[CH:17])=[O:16]

Participants

3

Reactant 2

HCID 239041PropargylamineHCID 18630276HCID 18630276, compound

Product 1

HCID 18630265HCID 18630265, compoundYield 85%

Procedure

The acid chloride prepared in Example 207 was reacted with propargylamine (3 eq) using General Method E1 to afford the title compound. Purification by recrystallization from hexanes gave 0.48 g of the title compound as an off-white solid in 85% yield. m.p. 109°-111° C.

Sources & evidence

ORD record
ord-f84b69568c3f4b2db5e2685906322a00
Source dataset
uspto-grants-1998_11
Patent number
US05834447

Reaction notes

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