3-Methyl-2-butanone → 1-(4-Benzyloxyphenyl)-4-methyl-pent-1-en-3-one

HRID 356451Notes

Reaction equation

HRID 356451 reaction equation
[CH3:1][CH:2]([CH3:6])[C:3](=[O:5])[CH3:4].[CH2:7]([O:14][C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Ba+2].[OH-]>CCO>[CH2:7]([O:14][C:15]1[CH:16]=[CH:17][C:18]([CH:19]=[CH:4][C:3](=[O:5])[CH:2]([CH3:6])[CH3:1])=[CH:21][CH:22]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 112513-Methyl-2-butanoneHCID 78109Benzaldehyde, 4-(phenylmethoxy)-HCID 6093286Barium hydroxide

Product 1

HCID 4714761-(4-Benzyloxyphenyl)-4-methyl-pent-1-en-3-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared as described in the General Method 2 using 81.1 g (942 mmol) of 3-methyl-butan-2-one, 100 g (474 mmol) of 4-benzyloxy benzaldehyde, 10 g of anhydrous barium hydroxide and 500 mL of EtOH.

Sources & evidence

ORD record
ord-5e5820244c6543a186f4751729a479ae
Source dataset
uspto-grants-1998_11
Patent number
US05834506

Reaction notes

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