HCID 317158, compound → HCID 12648138, compound

HRID 356461Notes

Reaction equation

HRID 356461 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])[CH:5]=[CH:6][CH:7]=1>[Pd].C1COCC1>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 317158HCID 317158, compound

Product 1

HCID 12648138HCID 12648138, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared as described in General Method 3 from 3-(3-hydroxy-phenyl)-1-phenyl-prop-2-en-1-one (8.0 g, 35.7 mmol), 5% Pd on BaSO4 (0.4 g), and THF (100 mL) at a reaction time of 2 hours. The crude product was purified by silica gel chromatography, eluting with EtOAc:hexane (10:90 to 25:75) to give the title compound, m.p. 81°-83° C.

Workup

  1. customThe title compound was prepared
  2. customThe crude product was purified by silica gel chromatography
  3. washeluting with EtOAc:hexane (10:90 to 25:75)

Sources & evidence

ORD record
ord-85ffd5a563fa4d31934c8ed6e619f0f0
Source dataset
uspto-grants-1998_11
Patent number
US05834506

Reaction notes

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