HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 3-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-phenyl-propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | NSC179363 | HCID 301514 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-phenyl-propan-1-one | HCID 18798703 | — |
Reaction Steps
The title compound was prepared as described in General Method 5 using 4.53 g (20 mmol) of 3-(4-hydroxy-phenyl)-1-phenyl-propan-1-one from Example L, 1.64 g (24 mmol) of imidazole, 3.62 g (24 mmol) of t-butyldimethylsilyl chloride and 80 mL of CH2Cl2. The product was carried on crude to the next step (see Example TT).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05834506 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-b9b64c909eb147c1964212c0e6ef1b8f |
| Source note | uspto-grants-1998_11 |