反应详情

A solution of 6.0 g N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide and 5.5 g 4-ethyl-3-thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours and treated in similar fashion to Example 67. Chromatography on silica gel and recrystalization from dichloromethane-hexane afforded 1.2 g yellow crystals, mp 225°-227° C.

1. additiontreated in similar fashion to Example 67
2. customChromatography on silica gel and recrystalization from dichloromethane-hexane