4-Ethyl-3-thiosemicarbazide → N-Methyl-N-[3-[3-(ethylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-Ethyl-3-thiosemicarbazide	HCID 1551780	—
Edukt	N-Methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide	HCID 15595702	—
Lösungsmittel	Ethanol	HCID 702	—
Produkt	N-Methyl-N-[3-[3-(ethylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide	HCID 15595690	16,9%

Reaktionsschritte

A solution of 6.0 g N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide and 5.5 g 4-ethyl-3-thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours and treated in similar fashion to Example 67. Chromatography on silica gel and recrystalization from dichloromethane-hexane afforded 1.2 g yellow crystals, mp 225°-227° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04767765
Quelldatensatz	uspto-grants-1988_08
ORD ID	ord-05f11d3529684d8dae78703e3aad4f88
Quellennotiz	uspto-grants-1988_08