HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 20230217, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone | HCID 739374 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 20230217 | HCID 20230217 | — |
Reaction Steps
Alkylation of 2',4'-dichloro-2-(1H-1,2,4-triazol-1-yl)acetophenone (8.64 g) with methyl iodide (5.27 g) in the presence of sodium hydride (as a 50% dispersion in oil, total weight of dispersion 1.78 g) in tetrahydrofuran (150 ml) at 0° over 2 hours, yielded the title compound which was isolated as a hydrochloride salt, m.p. 125°-129°, 3.17 g (yield 34.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04767777 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-933d869030304894b330f7e1415ebbc1 |
| Source note | uspto-grants-1988_08 |