Methyl iodide → HCID 20230217, compound

HRID 35657Notes

Reaction equation

HRID 35657 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[CH3:17]I.[H-].[Na+]>O1CCCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:16])[CH:10]([N:11]1[CH:15]=[N:14][CH:13]=[N:12]1)[CH3:17]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 7393741-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

Product 1

HCID 20230217HCID 20230217, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Alkylation of 2',4'-dichloro-2-(1H-1,2,4-triazol-1-yl)acetophenone (8.64 g) with methyl iodide (5.27 g) in the presence of sodium hydride (as a 50% dispersion in oil, total weight of dispersion 1.78 g) in tetrahydrofuran (150 ml) at 0° over 2 hours, yielded the title compound which was isolated as a hydrochloride salt, m.p. 125°-129°, 3.17 g (yield 34.8%).

Sources & evidence

ORD record
ord-933d869030304894b330f7e1415ebbc1
Source dataset
uspto-grants-1988_08
Patent number
US04767777

Reaction notes

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