Benzaldehyde → HCID 131720940, compound

HRID 356573Notes

Reaction equation

HRID 356573 reaction equation
[NH:1]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@H:2]([C:13]([NH:15][NH2:16])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[CH:24](=O)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[H][H]>CO.[C].[Pd]>[NH:1]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@H:2]([C:13]([NH:15][NH:16][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1

Participants

6

Reactant 3

HCID 240BenzaldehydeHCID 7109657HCID 7109657, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 131720940HCID 131720940, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

In 600 ml of MeOH were dissolved 60.00 g of Boc-Trp-NHNH2 and 21.00 g of benzaldehyde, and the mixture was stirred in the presence of 3.80 g of 10% palladium carbon for 18 hours in a hydrogen stream. Subsequent procedures were carried out in the same manner as in Reference example 21 to obtain the title compound.

Sources & evidence

ORD record
ord-ae587a596fb3412787507cfd02b84802
Source dataset
uspto-grants-1998_11
Patent number
US05837687

Reaction notes

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