Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylene Glycol → 2-(2-Methoxy-5-nitrophenyl)-1,3-dioxolane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | Benzaldehyde, 2-methoxy-5-nitro- | HCID 90685 | — |
| 촉매 | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| 생성물 | 2-(2-Methoxy-5-nitrophenyl)-1,3-dioxolane | HCID 18938964 | 80.5% |
반응 단계
A solution of 2-methoxy-5-nitrobenzaldehyde (100 g, 550 mmol), ethylene glycol (36.9 ml, 660 mmol) and CSA (5.00 g) was heated at reflux under dehydrating condition for 5 hr. After removal of the solvent, triethylamine (6 ml) was added to the residue and the mixture was recrystallized from first ethyl acetate and from next isopropanol to give 2-(2-methoxy-5-nitrophenyl)-1,3-dioxolane (99.7 g, 80.5%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05837711 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-7d60184a725840468aa4abdf627f8fd7 |
| 출처 메모 | uspto-grants-1998_11 |