反应详情

A solution of 2-methoxy-5-nitrobenzaldehyde (100 g, 550 mmol), ethylene glycol (36.9 ml, 660 mmol) and CSA (5.00 g) was heated at reflux under dehydrating condition for 5 hr. After removal of the solvent, triethylamine (6 ml) was added to the residue and the mixture was recrystallized from first ethyl acetate and from next isopropanol to give 2-(2-methoxy-5-nitrophenyl)-1,3-dioxolane (99.7 g, 80.5%) as a yellow solid.

1. temperatureat reflux
2. customfor 5 hr
3. customAfter removal of the solvent, triethylamine (6 ml)
4. additionwas added to the residue
5. customthe mixture was recrystallized from first ethyl acetate and from next isopropanol