Water → HCID 18938966, compound

HRID 356636Notes

Reaction equation

HRID 356636 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:13][CH3:14])=[C:6]([CH:8]2[O:12][CH2:11][CH2:10][O:9]2)[CH:7]=1.[CH3:15][S:16](Cl)(=[O:18])=[O:17].O.C([O-])(O)=O.[Na+]>N1C=CC=CC=1>[CH3:15][S:16]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([O:13][CH3:14])=[C:6]([CH:8]2[O:12][CH2:11][CH2:10][O:9]2)[CH:7]=1)(=[O:18])=[O:17]

Participants

6

Reactant 4

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 516892Sodium BicarbonateHCID 18938967HCID 18938967, compound

Product 1

HCID 18938966HCID 18938966, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 2-(5-amino-2-methoxyphenyl)-1,3-dioxolane (867 mg, 4.4 mmol) in pyridine (2 ml) was added methanesulfonyl chloride (375 μl, 4.84 mmol) and stirred for 20 hr. To the resulted reaction mixture was added water and aqueous NaHCO3, and then extracted with ether/CH2Cl2. The extract was evaporated in vacuo to give crude 2-(5-methylsulfonylamino-2-methoxyphenyl)-1,3-dioxolane (1.06 g, 88.1%) as a slight brown oil.

Workup

  1. customTo the resulted reaction mixture
  2. extractionextracted with ether/CH2Cl2
  3. customThe extract was evaporated in vacuo

Sources & evidence

ORD record
ord-4c6c2641fb2948aebdf46759a4e9c539
Source dataset
uspto-grants-1998_11
Patent number
US05837711

Reaction notes

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