反应详情

A solution of 2-[5-(N-methyl-N-methylsulfonylamino)-2-methoxyphenyl]-1,3-dioxolane (4.0 g, 13.9 mmol) in 1N-HCl (4 ml)/acetone (80 ml) was stirred at room temperature for 2 hr. After removal of the solvent, water was added to the residue and the mixture was extracted with CH2Cl2. The extract was washed with brine, dried over MgSO4 and evaporated in vacuo to give crude 5-(N-5-methyl-N-methylsulfonylamino)-o-anisaldehyde (4.0 g, 118%). The resulted crude compound was recrystallized from ethyl acetate/hexane to give 5-(N-methyl-N-methylsulfonylamino)-o-anisaldehyde (2.64. g, 81%).

1. customAfter removal of the solvent, water
2. additionwas added to the residue
3. extractionthe mixture was extracted with CH2Cl2
4. washThe extract was washed with brine
5. dry with materialdried over MgSO4
6. customevaporated in vacuo
7. customto give crude 5-(N-5-methyl-N-methylsulfonylamino)-o-anisaldehyde (4.0 g, 118%)
8. customThe resulted crude compound
9. customwas recrystallized from ethyl acetate/hexane