HRID356650

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID947

Nitrogen

HCID31275

1,4-Dioxane

C4H8O2

HCID5110493

pyridine-2-carbonyl azide

C6H4N4O

结构：COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc(C(C)C)cn3)ncnc2OCCO)c1

HCID18938932

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc(C(C)C)cn3)ncnc2OCCOC(=O)Nc2ccccn2)c1

HCID86753333

未命名化合物

CONDITIONS

反应条件

温度: 95 °C

PROCEDURE

实验过程

100 mg of N-[5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4-yl]-5-isopropyl-pyridine-2-sulphonamide and 38.5 mg of 2-pyridyl-carboxylic acid azide were dissolved in 1 ml of dry dioxan. The solution was stirred at 95° C. for 2 hours, whereby N2 was liberated. After distillation of the solvent the compound was crystallized from ethanol. 115 mg of pyridin-2-yl-carbamic acid 2-[5-(2-chloro-5-methoxy-phenoxy)-6-(5-isopropyl-pyridin-2-ylsulphonylamino)-pyrimidin-4-yloxy]-ethyl ester were obtained as white crystals with m.p. 190°-191° C.

WORKUP

后处理

distillationAfter distillation of the solvent the compound
customwas crystallized from ethanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7fa4fae288274be49a4a6fa9a5439110
来源数据集: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05837708
来源说明: uspto-grants-1998_11

反应 SMILES

[Cl:1][C:2]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:3]=1[O:4][C:5]1[C:6]([NH:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH:25]([CH3:27])[CH3:26])=[CH:21][N:20]=2)(=[O:18])=[O:17])=[N:7][CH:8]=[N:9][C:10]=1[O:11][CH2:12][CH2:13][OH:14].[N:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1C(N=[N+]=[N-])=O.[N:45]#N.[O:47]1[CH2:52]COCC1>>[Cl:1][C:2]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:3]=1[O:4][C:5]1[C:10]([O:11][CH2:12][CH2:13][O:14][C:52](=[O:47])[NH:45][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][N:34]=2)=[N:9][CH:8]=[N:7][C:6]=1[NH:15][S:16]([C:19]1[CH:24]=[CH:23][C:22]([CH:25]([CH3:27])[CH3:26])=[CH:21][N:20]=1)(=[O:18])=[O:17]