HCID 86753335, compound → HCID 86753334, compound

HRID 356656Notes

Reaction equation

HRID 356656 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=2)[N:5]=[C:4]([NH:17][S:18]([C:21]2[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:23][N:22]=2)(=[O:20])=[O:19])[C:3]=1[O:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37][CH3:38]>C(O)CO>[OH:30][CH2:31][CH2:32][O:37][C:2]1[N:7]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=2)[N:5]=[C:4]([NH:17][S:18]([C:21]2[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:23][N:22]=2)(=[O:20])=[O:19])[C:3]=1[O:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37][CH3:38]

Participants

3

Reactant 1

HCID 86753335HCID 86753335, compound

Product 1

HCID 86753334HCID 86753334, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

In analogy to Example 45, by reacting 5-isopropyl-pyridine-2-sulphonic acid [6-chloro-2-(3-methoxy-benzyl)-5-(2-methoxy- phenoxy)-pyrimidin-4-yl]-amide with Na in ethylene glycol there was obtained 5-isopropyl-pyridine-2-sulphonic acid [6-(2-hydroxy-ethoxy)-2-(3-methoxy-benzyl)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-amide as a white foam. MS: 579.3 (M-H)

Sources & evidence

ORD record
ord-58d5f4c0cae04fb682b36f225116b8bf
Source dataset
uspto-grants-1998_11
Patent number
US05837708

Reaction notes

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