4,6-Dichloro-2-(3-methoxy-benzyl)-5-phenoxy-pyrimidine → 5-Isopropyl-pyridine-2-sulphonic acid [6-chloro-2-(3-methoxy-benzyl)-5-phenoxy-pyrimidin-4-yl]-amide

HRID 356657Notes

Reaction equation

HRID 356657 reaction equation
Cl[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:6]([Cl:15])[N:5]=[C:4]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=2)[N:3]=1.[CH:25]([C:28]1[CH:29]=[CH:30][C:31]([S:34]([NH2:37])(=[O:36])=[O:35])=[N:32][CH:33]=1)([CH3:27])[CH3:26].[K]>>[Cl:15][C:6]1[N:5]=[C:4]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=2)[N:3]=[C:2]([NH:37][S:34]([C:31]2[CH:30]=[CH:29][C:28]([CH:25]([CH3:27])[CH3:26])=[CH:33][N:32]=2)(=[O:36])=[O:35])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 189389134,6-Dichloro-2-(3-methoxy-benzyl)-5-phenoxy-pyrimidineHCID 692894515-Isopropyl-pyridine-2-sulphonamide potassium

Product 1

HCID 867533365-Isopropyl-pyridine-2-sulphonic acid [6-chloro-2-(3-methoxy-benzyl)-5-phenoxy-pyrimidin-4-yl]-amide

Procedure

In analogy to Example 45, by reacting 4,6-dichloro-2-(3-methoxy-benzyl)-5-phenoxy-pyrimidine with potassium 5-isopropyl-pyridine-2-sulphonamide there was obtained 5-isopropyl-pyridine-2-sulphonic acid [6-chloro-2-(3-methoxy-benzyl)-5-phenoxy-pyrimidin-4-yl]-amide as a yellow foam. MS: 523 (M-H)

Sources & evidence

ORD record
ord-eb8b037486ed4fb5919ec3a88adef99a
Source dataset
uspto-grants-1998_11
Patent number
US05837708

Reaction notes

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