Hydrochloric Acid → HCID 9825033, compound

Participants

Reaction Steps

A mixture of N-(t-butoxycarbonyl)methyl-2-(3,4-dichlorophenyl)-N-[2-(3-(S)-hydroxypyrrolidin-1-yl)-1-(S)-phenylethyl]acetamide (306 mg, 0.6 mmol), HCl gas saturated methanol solution (8 ml), and methanol (2 ml) was refluxed with stirring for 2 h. After evaporation of the solvent, the resulting oil was crystallized from CH2Cl2 /MeOH to give 153 mg (52.3%) of desired compound as HCl salt of white powder.

Provenance & Evidence