Hydrochloric Acid → HCID 9825033, compound

HRID 356658Notes

Reaction equation

HRID 356658 reaction equation
C([O:5][C:6]([CH2:8][N:9]([C@@H:21]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:22][N:23]1[CH2:27][CH2:26][C@H:25]([OH:28])[CH2:24]1)[C:10](=[O:20])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=1)=[O:7])(C)(C)C.Cl>CO>[C:6]([CH2:8][N:9]([C@@H:21]([C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[CH2:22][N:23]1[CH2:27][CH2:26][C@H:25]([OH:28])[CH2:24]1)[C:10](=[O:20])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=1)([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18666906HCID 18666906, compound

Product 1

HCID 9825033HCID 9825033, compoundYield 56.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of N-(t-butoxycarbonyl)methyl-2-(3,4-dichlorophenyl)-N-[2-(3-(S)-hydroxypyrrolidin-1-yl)-1-(S)-phenylethyl]acetamide (306 mg, 0.6 mmol), HCl gas saturated methanol solution (8 ml), and methanol (2 ml) was refluxed with stirring for 2 h. After evaporation of the solvent, the resulting oil was crystallized from CH2Cl2 /MeOH to give 153 mg (52.3%) of desired compound as HCl salt of white powder.

Workup

  1. temperaturewas refluxed
  2. customAfter evaporation of the solvent
  3. customthe resulting oil was crystallized from CH2Cl2 /MeOH

Sources & evidence

ORD record
ord-2f6ffb4751ad4a2ba30bf20b9a956a98
Source dataset
uspto-grants-1998_11
Patent number
US05837720

Reaction notes

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