Trifluoroacetic acid → HCID 10683839, compound

HRID 356681Notes

Reaction equation

HRID 356681 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C@@H:11]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]([F:25])([F:24])[F:23])[C@H:10]([F:26])[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:26][C@H:10]1[C@H:11]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]([F:25])([F:23])[F:24])[CH2:12][CH2:13][NH:8][CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11793922HCID 11793922, compound

Product 1

HCID 10683839HCID 10683839, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using a similar procedure to that described in Example 1, step 4, trans-1-tert-butoxycarbonyl-3-fluoro-4-[2-(trifluoromethyl)benzylamino]piperidine (0.4615 g, 1.23 mmol) was reacted with trifluoroacetic acid (1.5 mL) in dichloromethane (3 mL) to give 0.3292 g (97%) of the title compound as a colourless oil. δH (360 MHz, CDCl3) 1.35 (1H, m), 2.02 (1H, m), 2.55-2.69 (2H, m), 2.82 (1H, m), 2.99 (1H, m), 3.31 (1H, m), 4.02 (2H, m), 4.34 (1H, two m), 7.35 (1H, t, J=7.6 Hz), 7.53 (1H, t, J=7.6 Hz), 7.63-7.67 (2H, m). m/e (ES+) 277 (M+H)+.

Sources & evidence

ORD record
ord-d375c712046c46c79efa025a6d4827f2
Source dataset
uspto-grants-1998_11
Patent number
US05837715

Reaction notes

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