Water → HCID 15055445, compound

HRID 356687Notes

Reaction equation

HRID 356687 reaction equation
[H-].[Na+].[OH:3][C:4]([C:7]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)=[O:8])([CH3:6])[CH3:5].[CH2:16](Br)[CH:17]=[CH2:18].O>CS(C)=O>[OH:3][C:4]([C:7]([C:9]1[CH:10]=[CH:11][C:12]([O:15][CH2:18][CH:17]=[CH2:16])=[CH:13][CH:14]=1)=[O:8])([CH3:5])[CH3:6]

Participants

6

Reactant 4

HCID 962WaterHCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 22239681110538-16-4

Product 1

HCID 15055445HCID 15055445, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

6.6 g (0.22 mol) of sodium hydride (80% strength in paraffin oil) are added in portions to 36.0 g (0.2 mol) of 4-hydroxyphenyl 2-hydroxy-2-propyl ketone in 450 ml of dimethyl sulfoxide under an inert gas and the mixture is stirred for 15 minutes at room temperature. 26.8 g (0.22 mol) of allyl bromide in 40 ml of dimethyl sulfoxide are then added dropwise at 30°-40° C., and the mixture is stirred for 15 minutes. The reaction mixture is poured into 2 l of water and then extracted with methyl t-butyl ether. By removing the solvent, 41.5 g of compound IIh are obtained.

Workup

  1. stirringthe mixture is stirred for 15 minutes
  2. extractionextracted with methyl t-butyl ether
  3. customBy removing the solvent, 41.5 g of compound IIh
  4. customare obtained

Sources & evidence

ORD record
ord-fdb8ed7a60814f1e9893e1fd18c4cae7
Source dataset
uspto-grants-1998_11
Patent number
US05837746

Reaction notes

Loading…