Hydrochloric Acid → Methyl 6-aminohexanoate

HRID 356884Notes

Reaction equation

HRID 356884 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].Cl.[CH3:11]O>>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH3:11])=[O:8]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 5646-Aminohexanoic AcidHCID 887Methanol

Product 1

HCID 1810164Methyl 6-aminohexanoateYield 75%

Procedure

To a suspension of 6-aminocaproic acid (3.00 g, 22.9 mmol) in anhydrous MeOH (60 mL) was introduced hydrogen chloride gas for 25 minutes, during which time the suspension became clear. The solution was then stirred at room temperature for 5 hours and MeOH was removed in vacuo. The residue was recrystallized from THF to give a white solid (3.10 g). (Yield: 75%).

Workup

  1. customMeOH was removed in vacuo
  2. customThe residue was recrystallized from THF

Sources & evidence

ORD record
ord-766bdc59025b47d591183ae4394f4acb
Source dataset
uspto-grants-1998_11
Patent number
US05840733

Reaction notes

Loading…