Lithium borohydride → HCID 22145918, compound

HRID 356894Notes

Reaction equation

HRID 356894 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8](OCC)=[O:9])[CH:5]=[C:4]([Cl:13])[C:3]=1[NH:14][C:15](=[O:30])[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)[CH:17]=1.[BH4-].[Li+]>O1CCCC1.[Cl-].[Na+].O>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([Cl:13])[C:3]=1[NH:14][C:15](=[O:30])[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH:25]2[CH2:26][CH2:27][CH2:28][CH2:29]2)[CH:17]=1

Participants

5

Reactant 2

HCID 4148881Lithium borohydrideHCID 22145785HCID 22145785, compound

Product 1

HCID 22145918HCID 22145918, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent2×HCID 57417360Sodium chloride; waterSolvent

Procedure

A stirred solution of N-(2,6-dichloro-4-ethoxycarbonylphenyl)-3-cyclopentyloxy-4-methoxybenzamide (6.1 g; that is prepared as described in Example 8) in dry tetrahydrofuran (80 mL) at room temperature under argon is treated dropwise with a solution of lithium borohydride in tetrahydrofuran (115 mL; 2 M). The mixture is stirred overnight and then it is treated portionwise with saturated brine (200 mL) and stirred for 30 minutes. The organic layer is then washed with water, dried over magnesium sulfate and evaporated. The resulting residue is subjected to flash chromatography on silica gel, to give N-(2,6-dichloro-4-hydroxymethylphenyl)-3-cyclopentyloxy-4-methoxybenzamide (4.4 g), m.p. 174°-176° C. [Elemental analysis: C,57.1; H,5.4; N,2.9%; calculated C20H21O4NCl2 :0.5H2 O: C,57.3; H,5.3; N,3.3%]

Workup

  1. customthat is prepared
  2. customat room temperature
  3. stirringstirred for 30 minutes
  4. washThe organic layer is then washed with water
  5. dry with materialdried over magnesium sulfate
  6. customevaporated

Sources & evidence

ORD record
ord-ea8685308d734134b42485fe3e682a56
Source dataset
uspto-grants-1998_11
Patent number
US05840724

Reaction notes

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