Formamide → Hydrochloric Acid

HRID 35697Notes

Reaction equation

HRID 35697 reaction equation
C([NH:3][CH:4]([C:6]1([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[CH2:9][CH2:8][CH2:7]1)[CH3:5])=O.C(N)=O>>[ClH:16].[Cl:17][C:12]1[CH:11]=[C:10]([C:6]2([CH:4]([NH2:3])[CH3:5])[CH2:9][CH2:8][CH2:7]2)[CH:15]=[CH:14][C:13]=1[Cl:16]

Participants

4

Reactant 2

HCID 713FormamideHCID 23292610N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine

Product 2

HCID 313Hydrochloric AcidHCID 130831401-[1-(3,4-Dichlorophenyl)cyclobutyl]ethylamine

Procedure

The preparation of N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine (m.p. 124°-125° C.) (Example 1(a) Formula I R1 =Me; R2 =H; R3 =H; R4 =CHO; R5 =4--Cl and R6 =3--Cl) described above was repeated and the product isolated by cooling the reaction mixture and collecting the solid produced by filtration. The formamide was then hydrolysed by concentrated hydrochloric acid in industrial methylated spirit to give the hydrochloride salt of 1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine.

Workup

  1. customthe product isolated
  2. temperatureby cooling the reaction mixture
  3. customcollecting the solid
  4. customproduced by filtration

Sources & evidence

ORD record
ord-484fc551f446422ab90c75b5447a20f6
Source dataset
uspto-grants-1988_08
Patent number
US04767790

Reaction notes

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