Trifluoroacetic acid → HCID 54415324, compound

HRID 356980Notes

Reaction equation

HRID 356980 reaction equation
[F:1][C:2]1[CH:45]=[CH:44][C:5]([CH2:6][N:7]([CH:27]([CH2:36][CH2:37][C:38]2[CH:43]=[CH:42][N:41]=[CH:40][CH:39]=2)[CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=2)[C:8](=[O:26])[C@@H:9]([NH:17][C:18](=O)N(C)C(C)(C)C)[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]([CH:27]([CH2:28][CH2:29][C:30]2[CH:31]=[CH:32][N:33]=[CH:34][CH:35]=2)[CH2:36][CH2:37][C:38]2[CH:39]=[CH:40][N:41]=[CH:42][CH:43]=2)[C:8](=[O:26])[C@@H:9]([NH:17][CH3:18])[CH2:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:44][CH:45]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 20638935HCID 20638935, compound

Product 1

HCID 54415324HCID 54415324, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 4 was dissolved in methylene chloride (10 mL) and treated with trifluoroacetic acid (4.0 mL). After stirring at room temperature for 1.5 h, the reaction was concentrated in vacuo. The residue was neutralized with saturated potassium carbonate and extracted with ethyl acetate (2×). The extracts were combined, washed with water, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to provide Compound 5.

Workup

  1. concentrationthe reaction was concentrated in vacuo
  2. extractionextracted with ethyl acetate (2×)
  3. washwashed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2f0bb02615924865ac0adb61fdfb7ece
Source dataset
uspto-grants-1998_11
Patent number
US05840736

Reaction notes

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