反应详情

To a solution of 19.28 g (150 mmol) of 2-amino-6-chloropyridine in 150 ml of ethanol, 25 g (180 mmol) of bromoacetone was added at room temperature, followed by refluxing for 64 hours. After the reaction mixture was cooled, the solvent was distilled off. The residue was purified by recrystallization (solvent: ethanol-ethyl acetate) to yield 20.22 g (54.5%, light brown crystal) of the desired product.

1. temperatureby refluxing for 64 hours
2. temperatureAfter the reaction mixture was cooled
3. distillationthe solvent was distilled off
4. customThe residue was purified by recrystallization (solvent: ethanol-ethyl acetate)