HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazolidinedione → 3-[4-(2-Methylimidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 5-(4-Chlorobutylthio)-2-methylimidazo[1,2-a]pyridine | HCID 18936662 | — |
| Product | 3-[4-(2-Methylimidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione | HCID 18936835 | — |
Reaction Steps
Using 0.76 g (3.0 mmol) of 5-(4-chlorobutylthio)-2-methylimidazo[1,2-a]pyridine, 0.35 g (3.0 mmol) of thiazolidine-2,4-dione and 0.45 ml (3.0 mmol) of 1,8-diazabicyclo[5.4.0]-7-undecene, the same procedure as in Reference Example 2 was followed, to yield 0.78 g (77.7%, light yellow oily substance) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05840732 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-0fcb5d6fc33a4613981ea0a04354f989 |
| Source note | uspto-grants-1998_11 |