Chloroacetaldehyde → 3-[4-(Imidazo[1,2-a]pyridin-8-yloxy)butyl]oxazolidine-2,4-dione

HRID 357029Notes

Reaction equation

HRID 357029 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]2[C:17](=[O:18])[CH2:16][O:15][C:14]2=[O:19])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[CH2:21][CH:22]=O>>[N:1]1[CH:21]=[CH:22][N:3]2[CH:4]=[CH:5][CH:6]=[C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]3[C:17](=[O:18])[CH2:16][O:15][C:14]3=[O:19])[C:2]=12

Participants

3

Reactant 2

HCID 33ChloroacetaldehydeHCID 189367213-[4-(2-Aminopyridin-3-yloxy)butyl]oxazolidine-2,4-dione

Product 1

HCID 189367393-[4-(Imidazo[1,2-a]pyridin-8-yloxy)butyl]oxazolidine-2,4-dione

Procedure

Using 6.63 g (25 mnmol) of 3-[4-(2-aminopyridin-3-yloxy)butyl]oxazolidine-2,4-dione and 25 ml of a 40% chloroacetaldehyde solution, the same procedure as in Reference Example 18 was followed, to yield 6.48 g (89.5%, yellow oily substance) of the desired product.

Sources & evidence

ORD record
ord-5dcf9e7728964d3c82a9fe8ead9d4460
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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