Hydrochloric Acid → 5-Decylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

HRID 357040Notes

Reaction equation

HRID 357040 reaction equation
[CH:1](=[C:11]1[S:15][C:14](=[O:16])[N:13]([CH2:17][CH2:18][CH2:19][CH2:20][S:21][C:22]2[N:27]3[CH:28]=[CH:29][N:30]=[C:26]3[CH:25]=[CH:24][CH:23]=2)[C:12]1=[O:31])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[ClH:32]>CO>[ClH:32].[CH:1](=[C:11]1[S:15][C:14](=[O:16])[N:13]([CH2:17][CH2:18][CH2:19][CH2:20][S:21][C:22]2[N:27]3[CH:28]=[CH:29][N:30]=[C:26]3[CH:25]=[CH:24][CH:23]=2)[C:12]1=[O:31])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 572335115-Decylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione

Product 1

HCID 734729515-Decylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2.24 g (4.87 mmol) of 5-decylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 50 ml of methanol, 0.55 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 2.38 g (98%, light yellow solid) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-020aed2376b44624a989ea38cb1704b7
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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