Hydrochloric Acid → 3-[4-(Imidazo[1,2-a]pyridin-5-ylthio)-butyl]-5-butylidenehydantoin hydrochloride

HRID 357064Notes

Reaction equation

HRID 357064 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:19](=[O:20])[C:18](=[CH:21][CH2:22][CH2:23][CH3:24])[NH:17][C:16]3=[O:25])=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:26]>CO>[ClH:26].[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3[C:19](=[O:20])[C:18](=[CH:21][CH2:22][CH2:23][CH3:24])[NH:17][C:16]3=[O:25])=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 572685863-[4-(Imidazo[1,2-a]pyridin-5-ylthio)-butyl]-5-butylidenehydantoin

Product 1

HCID 702054923-[4-(Imidazo[1,2-a]pyridin-5-ylthio)-butyl]-5-butylidenehydantoin hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.43 g (1.20 mmol) of 3-[4-(imidazo-[1,2-a]pyridin-5-ylthio)butyl]-5-butylidenehydantoin in 10 ml of methanol, 0.17 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 0.53 g (100%, brown solid) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-ca1d0557b519414bb762b89dd0c8c744
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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