Hydrochloric Acid → 5-(3-Phenylpropylidene)-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

HRID 357066Notes

Reaction equation

HRID 357066 reaction equation
[C:1]1([CH2:7][CH2:8][CH:9]=[C:10]2[S:14][C:13](=[O:15])[N:12]([CH2:16][CH2:17][CH2:18][CH2:19][S:20][C:21]3[N:26]4[CH:27]=[CH:28][N:29]=[C:25]4[CH:24]=[CH:23][CH:22]=3)[C:11]2=[O:30])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:31]>CO>[ClH:31].[C:1]1([CH2:7][CH2:8][CH:9]=[C:10]2[S:14][C:13](=[O:15])[N:12]([CH2:16][CH2:17][CH2:18][CH2:19][S:20][C:21]3[N:26]4[CH:27]=[CH:28][N:29]=[C:25]4[CH:24]=[CH:23][CH:22]=3)[C:11]2=[O:30])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 573054705-(3-Phenylpropylidene)-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione

Product 1

HCID 734729435-(3-Phenylpropylidene)-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2.27 g (5.0 mmol) of 5-(3-phenylpropylidene)-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 50 ml of methanol, 0.5 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 2.29 g (100%, brown oily substance) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-4a6247133de54d8f8e14bc3de2869714
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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