Hydrochloric Acid → 5-Butylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione hydrochloride

HRID 357069Notes

Reaction equation

HRID 357069 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([CH:22]=[CH:23][N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:25])[CH2:2][CH2:3][CH3:4].[ClH:26]>CO>[ClH:26].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([CH:22]=[CH:23][N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:25])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 572057075-Butylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione

Product 1

HCID 734729505-Butylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.44 g (4.0 mmol) of 5-butylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione in 20 ml of methanol, 0.4 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 1.58 g (quant, yellow oily substance) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-48ccf95c308540ca84e4e177d7ef53bf
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

Loading…