Hydrochloric Acid → 5-Butylidene-3-[4-(2-methyl-imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

HRID 357071Notes

Reaction equation

HRID 357071 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15][C:16]2[N:21]3[CH:22]=[C:23]([CH3:25])[N:24]=[C:20]3[CH:19]=[CH:18][CH:17]=2)[C:6]1=[O:26])[CH2:2][CH2:3][CH3:4].[ClH:27]>CO>[ClH:27].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15][C:16]2[N:21]3[CH:22]=[C:23]([CH3:25])[N:24]=[C:20]3[CH:19]=[CH:18][CH:17]=2)[C:6]1=[O:26])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 572386885-Butylidene-3-[4-(2-methyl-imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione

Product 1

HCID 734729405-Butylidene-3-[4-(2-methyl-imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.794 g (2.0 mmol) of 5-butylidene-3-[4-(2-methyl-imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 10 ml of methanol, 0.25 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 0.801 g (94.0%, light yellow solid) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-dd7421eb8c7b4d01a06fefdcb3d426e9
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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