Hydrochloric Acid → 7-[4-(imidazo[1,2-a]pyridin-5-ylthio)-butyl]-1,1-dioxo-9-phenyl-3,4-dihydro-2H,6H-pyrimido[6,1-b][1,3]thiazine-6,8(7H)-dione hydrochloride

Participants

Reaction Steps

To a solution of 1.26 g (2.61 mmol) of 7-[4-(imidazo-[1,2-a]pyridin-5-ylthio)butyl]-1,1-dioxo-9-phenyl-3,4-dihydro-2H,6H-pyrimido[6,1-b][1,3]thiazine-6,8(7H)-dione in 20 ml of methanol, 0.25 ml (3 mmol) of concentrated hydrochloric acid was added. After the reaction mixture was concentrated to dryness, diethyl ether was added to the residue. The resulting crystal was collected by filtration and dried to yield 1.35 g (quant, light white crystal) of the desired product.

Provenance & Evidence